Publications

PXL01 and Anti–Adhesion

• Wiig M, Dahlin LB, Fridén J, Hagber L, Larsen SE, Mahlapuu M. (2014). PXL01 in sodium hyaluronate for improvement of hand recovery after flexor tendon repair surgery: randomized controlled trial. PLOS ONE, 9(10):e110735.
• Håkansson J, Mahlapuu M, Ekström L, Olmarker K, Wiig M. (2012). Effect of Lactoferrin Peptide (PXL01) on Rabbit Digit Mobility after Flexor Tendon Repair. J. Hand Surg., 37(12):2519-25.
• Wiig M, Olmarker K, Håkansson J, Ekström L, Nilsson E, Mahlapuu M. (2011).A lactoferrin-derived peptide (PXL01) for the reduction of adhesion formation in flexor tendon surgery: an experimental study in rabbits. J. Hand Surg., 36(8):656-62.
• Olmarker K, Ekström L Håkansson J, Nilsson E, Wiig M, Mahlapuu M. (2010). Model for assessment of mobility of toes and healing of tendons in rabbits. J. Plast. Surg. & Hand Surg. 44(6):266-71.
• Nilsson E, Björn C, Sjöstrand V, Lindgren K, Münnich M, Mattsby-Baltzer I, Ivarsson M-L, Olmarker K, Mahlapuu M. (2009).A novel polypeptide derived from human lactoferrin in sodium hyaluronate prevents post-surgical adhesion formation in the rat. Ann. Surg., 250(6):1021-8.
• Shaw TJ, Martin P. (2009) Wound repair at a glance. J Cell Sci., 122(18): 3209–3213.

LL-37 and Chronic Wounds

• Grönberg A, Mahlapuu M, Ståhle M, Whately-Smith C, Rollman O. (2014).Treatment with LL-37 is safe and effective in enhancing healing of hard-to-heal venous leg ulcers: A randomized, placebo-controlled clinical trial. Wound Repair & Regenerat, 22(5):613-21.
• Rivas-Santiago B, Trujillo V, Montoya A, Gonzalez-Curiel I, Castaneda-Delgado J et al. (2012).Expression of antimicrobial peptides in diabetic foot ulcer. J Dermatol Sci, 65:19–26.
• Ramos R, Silva JP, Rodrigues AC, Costa R, Guardao L, Schmitt F et al. (2011).Wound healing activity of the human antimicrobial peptide LL-37. Peptides, 32:1469–76.
• Tokumaru S, Sayama K et al. (2005). Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37. J Immunol, 175(7):4662-8.
• Koczulla R, von Degenfeld G, Kupatt C, Krotz F, Zahler S, Gloe T, Issbrucker K et al. (2003).An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Invest, 111(11):1665-72.
• Scott MG, Davidson DJ, Gold MR, Bowdish D, Hancock RE. (2002). The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J Immunol, 169(7):3883-3891
• Dorschner RA1, Pestonjamasp VK, Tamakuwala S, Ohtake T, Rudisill J, Nizet V, Agerberth B, Gudmundsson GH,Gallo RL. (2001). Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus. J Invest Dermatol, 117(1):91-7.